Whether synaptotagmin is the calcium sensor in transmitter release has been controversial. Two studies now highlight how calcium binding to synaptotagmin might support this function.
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O'Connor, V., Lee, A. Synaptic vesicle fusion and synaptotagmin: 2B or not 2B?. Nat Neurosci 5, 823–824 (2002). https://doi.org/10.1038/nn0902-823
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DOI: https://doi.org/10.1038/nn0902-823
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