New evidence identifies γδ T cells as key players in both epithelial defense and the regulation of innate and acquired immune responses.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Changes in γδT Cells in Peripheral Blood of Patients with Ulcerative Colitis Exacerbations
Archivum Immunologiae et Therapiae Experimentalis Open Access 21 July 2021
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zuany-Amorim, C. et al. Requirement for γδ T cells in allergic airway inflammation. Science 280, 1265–1267 (1998).
Groh, V., Steinle, A., Bauer, S. & Spies, T. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279, 1737–1740 (1998).
Mallick-Wood, C.A. et al. Conservation of T-cell receptor conformation in epidermal γδ T cells with disrupted primary Vδ gene usage. Science 279, 1729–1733 (1998).
Saito, H. et al. Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 280, 275–277 (1998).
Toyonaga, B. & Mak, T.W. Genes of the T-cell antigen receptor in normal and malignant T cells. Ann. Rev. Immunol. 5, 585–620 (1987).
Schild, H. et al. The nature of major histocompatibility complex recognition by γδ T cells. Cell 76, 29–37 (1994).
Havran, W.L., Chien, Y.H. & Allison, J.P. Recognition of self antigens by skin-derived T cells with invariant γδ antigen receptors. Science 252, 1430–1432 (1991).
Boismenu, R. & Havran, W.L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266, 1253–1255 (1994).
Boismenu, R. et al. Chemokine expression by intraepithelial γδ T cells Implications for the recruitment of inflammatory cells to damaged epithelia. J. Immunol. 157, 985–992 (1996).
Ferrick, D.A. et al. Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by δ T cells in vivo. Nature 373, 255–257 (1995).
Wen, L. et al. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by ‘non α/γ’ T cells. J. Exp. Med. 183, 2271–2282 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mak, T., Ferrick, D. The γδ T-cell bridge: Linking innate and acquired immunity. Nat Med 4, 764–765 (1998). https://doi.org/10.1038/nm0798-764
Issue Date:
DOI: https://doi.org/10.1038/nm0798-764
This article is cited by
-
Changes in γδT Cells in Peripheral Blood of Patients with Ulcerative Colitis Exacerbations
Archivum Immunologiae et Therapiae Experimentalis (2021)
-
γδ T Cells Contribute to the Outcome of Murine Fulminant Viral Hepatitis via Effector Cytokines TNF-α and IFN-γ
Current Medical Science (2018)
-
Immunosenescence and cancer vaccines
Cancer Immunology, Immunotherapy (2009)
-
Differential TCR gene usage between WC1 − and WC1 + ruminant γδ T cell subpopulations including those responding to bacterial antigen
Immunogenetics (2006)
-
Induction of αδ- and αβ-mediated T cell responses in healthy elderly subjects after influenza vaccination
Biogerontology (2006)