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Transglutaminase, gluten and celiac disease: Food for thought

Nature Medicine volume 3, pages 725–726 (1997)Cite this article

Tansglutaminase is identified as the autoantigen or celiac disease (pages 797–801).

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References

  1. Kumar, V.J. et al. Endomysial antibodies in the diagnosis of celiac disease and the effect of gluten on antibody titers. Immunol. Invest. 18, 533–544 (1989).

    Article  CAS  Google Scholar 

  2. Dieterich, W. et al. Identification of tissue transglutaminase as the autoantigen of coeliac disease. Nature Med. 3, 797–801 (1997).

    Article  CAS  Google Scholar 

  3. Peters, T.J. & Bjarnason, I. Coeliac syndrome: biochemical mechanisms and the missing peptidase hypothesis revisited. Gut 25, 913–918 (1984).

    Article  CAS  Google Scholar 

  4. Marsh, M.N. Gluten, major histocompatibility complex, and the small intestine: A molecular and immunobiologic approach to the spectrum of gluten-sensitivity (“celiac sprue”). Gastroenterology 102, 330–354 (1992).

    Article  CAS  Google Scholar 

  5. Trejdosiewicz, L.K. & Howdle, P.D. T-cell responses and cellular immunity in coeliac disease. In Coeliac Disease (ed. Howdle, P.D.) 251–272 (Balliere Tindall, Philadelphia, 1995).

    Google Scholar 

  6. Ferguson, A. Models of immunologically-driven small intestinal damage. In Immunopathology of the Small Intestine (ed. Marsh, M. N.) 225–252 (Wiley, Chichester, 1987).

    Google Scholar 

  7. MacDonald, T.T. T cell-mediated intestinal injury. In Coeliac Disease (ed. Marsh, M.N.) 283–304 (Blackwell, Oxford, 1992).

    Google Scholar 

  8. Marsh, M.N. & Cummins, A.G. The interactive role of mucosal T lymphocytes in intestinal growth, development and enteropathy. J. Gastroenterol. Hepatology, 8 270–278.

    Article  CAS  Google Scholar 

  9. Nilsen, E.M., Lundkin, K.E. & Krajci, P. Gluten specific HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon-γ. Gut 37, 766–776 (1995).

    Article  CAS  Google Scholar 

  10. Marsh, M.N. Mucosal pathology in gluten sensitivity. In Coeliac Disease (ed. Marsh, M.N.) 136–191 (Blackwell, Oxford, 1992).

    Google Scholar 

  11. Pender, S.L.F., Lionetti, P., Murch, S.H., Wathan, N. & MacDonald, T.T. Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation. Gut 39, 284–290 (1996).

    Article  CAS  Google Scholar 

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  1. University Department of Medicine, Hope Hospital, Salford, M6 8HD, Manchester, U.K.

    Michael N. Marsh

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  1. Michael N. Marsh
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Marsh, M. Transglutaminase, gluten and celiac disease: Food for thought. Nat Med 3, 725–726 (1997). https://doi.org/10.1038/nm0797-725

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