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Another way to generate T cells?

Oncostatin M stimulates extrathymic generation of T lymphocytes.

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References

  1. Clegg, C.H., Rulffes, J.T., Wallace, P.M. & Haugen, H.S. Regulation of an extrathymic T-Cell development pathway by oncostatin M. Nature 384, 261–263 (1996).

    Article  CAS  Google Scholar 

  2. Zheng, B., Han, S., Zhu, Q., Goldsby, R. & Kelsoe, G. Alternative pathways for the selection of antigen-specific peripheral T Cells. Nature 384, 263–266 (1996).

    Article  CAS  Google Scholar 

  3. Shortman, K. & Wu, L. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14, 29–47 (1996).

    Article  CAS  Google Scholar 

  4. Osborne, B.A. Apoptosis and maintenance of homeostasis in the immune system. Curr. Opin. Immunol. 8, 245–254 (1996).

    Article  CAS  Google Scholar 

  5. Metcalf, D. The autonomous behaviour of normal thymus grafts. Aust. J. Exp. Biol. Med. Sci. 41, 437–448 (1963).

    Article  Google Scholar 

  6. Zuniga-Pflucker, J.C. & Leonardo, M.J. Regulation of thymocyte development from immature progenitors. Curr. Opin. Immunol. 8, 215–224 (1996).

    Article  CAS  Google Scholar 

  7. Rocha, B., Guy-Grand, D. & Vassalli, P. Extrathymic T-Cell differentiation. Curr. Opin. Immunol. 7, 235–242 (1995).

    Article  CAS  Google Scholar 

  8. Shen, M.M. et al. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 13, 1375–1385 (1994).

    Article  CAS  Google Scholar 

  9. Metcalf, D. Implications of the polyfunctionality of hemopoietic regulators. Stem Cells 12 (Suppl. 1), 259–275 (1994)

    Article  Google Scholar 

  10. Yoshida, K. et al. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA 93, 407–411 (1996).

    Article  CAS  Google Scholar 

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Metcalf, D. Another way to generate T cells?. Nat Med 3, 18–19 (1997). https://doi.org/10.1038/nm0197-18

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