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Killed by leukocytes that don't know when to leave

Nature Immunology volume 3, pages 337–338 (2002)Cite this article

Patients with severe asthma accumulate inflammatory cells in their airway walls. Studies with MMP2-deficient mice now show that an inability of these cells to egress from the lung can be fatal.

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Figure 1: Genetic deletion or pharmacologic blockade of MMP2 inhibits the movement of leukocytes from the airway stromal compartment to the airway lumen.

Bob Crimi

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  1. Lung Biology Center, Box 0854, University of California San Francisco, San Francisco, 94110, CA, USA

    Dean Sheppard

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  1. Dean Sheppard
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Sheppard, D. Killed by leukocytes that don't know when to leave. Nat Immunol 3, 337–338 (2002). https://doi.org/10.1038/ni0402-337

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