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Toward a human epigenome

Nature Genetics volume 38, pages 1359–1360 (2006)Cite this article

Sequencing of genomes, including that of humans, has revolutionized our understanding of genome organization and accelerated the hunt for disease-causing mutations. New studies by the Human Epigenome Project (HEP) now highlight the importance and complexity of cytosine DNA methylation in tissue-specific regulation of gene expression.

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Figure 1: Tissue-specific DNA methylation and epigenetic heterogeneity among individuals.

Kim Caesar

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Authors and Affiliations

  1. Division of Human Cancer Genetics, Department of Molecular Genetics and Department of Molecular Virology, Immunology and Medical Genetics,

    Romulo M Brena, Tim H-M Huang & Christoph Plass

  2. Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, 43210, Ohio, USA

    Romulo M Brena, Tim H-M Huang & Christoph Plass

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  1. Romulo M Brena
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  2. Tim H-M Huang
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  3. Christoph Plass
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Brena, R., Huang, TM. & Plass, C. Toward a human epigenome. Nat Genet 38, 1359–1360 (2006). https://doi.org/10.1038/ng1206-1359

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