Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Separate Helper Functions provided by Adenovirus for Adenovirus-associated Virus Multiplication

Nature New Biology volume 244, pages 71–73 (1973)Cite this article

An Erratum to this article was published on 22 August 1973

Abstract

ADENOVIRUS-ASSOCIATED viruses (AAV) are small, DNA parvoviruses which are unable to multiply in cell culture unless cells are also infected with a helper adenovirus1. Furthermore, natural infection in man also requires co-infection with helper virus2. It has been shown that AAV multiplication is defective at some step(s) subsequent to adsorption of the virus and uncoating of the viral DNA3. In addition, there is evidence that both complete helpers (adenoviruses) and partial helpers (herpes viruses) provide one or more functions required for synthesis of AAV DNA and RNA3,4 and antigen5,6. Helper viruses contain a double stranded genome, whereas the AAV genome is single stranded. Also unlike any other animal viruses, AAV particles contain either a “plus” or “minus” strand of DNA7,8.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Atchison, R. W., Casto, B. C., and Hammon, W. McD., Science, 149, 754 (1965).

    Article  CAS  Google Scholar 

  2. Blacklow, N. R., Hoggan, M. D., Kapikian, A. Z., Austin, J. B., and Rowe, W. D., Amer. J. Epidemiol., 88, 368 (1968).

    Article  CAS  Google Scholar 

  3. Rose, J. A., and Koczot, F., J. Virol., 10, 1 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Carter, B. J., and Rose, J. A., J. Virol., 10, 9 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Atchison, R. W., Virology, 42, 155 (1970).

    Article  CAS  Google Scholar 

  6. Blacklow, N. R., Hoggan, M. D., and McClanahan, M., Proc. Soc. Exp. Biol. Med., 134, 952 (1970).

    Article  CAS  Google Scholar 

  7. Rose, J. A., Berns, K. I., Hoggan, M. D., and Koczot, F. J., Proc. US Nat. Acad. Sci., 64, 863 (1969).

    Article  CAS  Google Scholar 

  8. Berns, K. I., and Rose, J. A., J. Virol., 5, 693 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Bourgaux, P., Bourgaux-Ramoisy, D., and Dulbecco, R., Proc. US Nat. Acad. Sci., 64, 701 (1969).

    Article  CAS  Google Scholar 

  10. Rose, J. A., and Koczot, F., J. Virol., 8, 771 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Waarner, S. O., and Cohen, J. A., Biochem. Biophys. Res. Commun., 24, 554 (1966).

    Article  Google Scholar 

  12. Green, M., Cold Spring Harbor Symp. Quant. Biol., 27, 219 (1962).

    Article  CAS  Google Scholar 

  13. Green, M., Parsons, J. T., Piña, M., Fujinaga, K., Caffier, H., and Landgraf-Leurs, I., Cold Spring Harbor Symp. Quant. Biol., 35, 803 (1970).

    Article  CAS  Google Scholar 

  14. Reich, P. R., Baum, S. G., Rose, J. A., Rowe, W. P., and Weissman, S. M., Proc. US Nat. Acad. Sci., 55, 336 (1966).

    Article  CAS  Google Scholar 

  15. Flanagan, T. F., and Ginsberg, H., J. Exp. Med., 116, 141 (1962).

    Article  CAS  Google Scholar 

  16. Garon, C. F., Berry, K. W., and Rose, J. A., Proc. US Nat. Acad. Sci., 69, 2391 (1972).

    Article  CAS  Google Scholar 

  17. Carter, B. J., Khoury, G., and Rose, J. A., J. Virol., 10, 1118 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Koczot, F., Carter, B. J., Garon, C. F., and Rose, J. A., Proc. US Nat. Acad. Sci., 70, 215 (1973).

    Article  CAS  Google Scholar 

  19. Henry, C. J., Merkow, L. P., Pardo, M., and McCabe, C., Virology, 49, 618 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Biology of Viruses and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, 20014

    BARRIE J. CARTER, FRANK J. KOCZOT, JAMES GARRISON, JAMES A. ROSE & RAPHAEL DOLIN

Authors
  1. BARRIE J. CARTER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. FRANK J. KOCZOT
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. JAMES GARRISON
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. JAMES A. ROSE
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. RAPHAEL DOLIN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CARTER, B., KOCZOT, F., GARRISON, J. et al. Separate Helper Functions provided by Adenovirus for Adenovirus-associated Virus Multiplication. Nature New Biology 244, 71–73 (1973). https://doi.org/10.1038/newbio244071a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio244071a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing