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N-Methylation of Dopamine to Epinine in Brain Tissue using N-Methyltetrahydrofolic Acid as the Methyl Donor

Nature New Biology volume 238, pages 212–213 (1972)Cite this article

Abstract

DURING biosynthetis of catecholamines, the final step in adrenaline formation involves transfer of a methyl group from S-adenosylmethionine (SAM) to the nitrogen of noradrenaline1; such N-methylation has been demonstrated in vitro with dopamine by the use of an enzyme from the adrenal medulla2. We propose a simplified model more compatible with the concept of intracellular compartments; in our model epinine should be considered as the immediate precursor of adrenaline2.

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Authors and Affiliations

  1. Department of Neurobiochemistry, Janssen Pharmaceutica, B-2340, Beerse, Belgium

    PIERRE LADURON

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  1. PIERRE LADURON
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LADURON, P. N-Methylation of Dopamine to Epinine in Brain Tissue using N-Methyltetrahydrofolic Acid as the Methyl Donor. Nature New Biology 238, 212–213 (1972). https://doi.org/10.1038/newbio238212a0

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