Erratum: Organocatalytic atroposelective synthesis of axially chiral styrenes

This corrects the article DOI: 10.1038/ncomms15238.


Preparation of 2b-2h
Bis[triphenylphosphine]palladium dichloride (1.0 mmol, 0.05 equiv) and copper iodide (1.2 mmol, 0.06 equiv) were added to a to a solution of aryl iodide (20 mmol, 1.0 equiv) in trimethylamine (50 mL) at room temperature. The reaction was allowed to stir 10 minutes, and then propargyl alcohol (22 mmol, 1.1 equiv) was added to the mixture. After reaction complete (monitored by TLC) TEA was evaporated and the residue was washed with sat NH 4 Cl (50 mL), extracted with CH 2 Cl 2 (2 x 150 mL) and dry over Na 2 SO 4 . After concentration the crude product was purified by column chromatography (silica gel, PE/EA 5/1) affording desired alcohol.

Supplementary Note 3 General procedure for preparation of racemic compound 3
Diisopropylamine (20 mol%) was added to a solution of 1(0.05 mmol) and 2 (0.06 mmol) in methylene chloride (0.5 mL). And the mixture was stirred till 1 was completely consumed (monitored by TLC).
The mixture was concentrated under reduced pressure and purified by flash chromatography on silica gel and eluted with PE/EA (8/1 to 3/1) to afford the corresponding desired racemic product 3.

Chiral HPLC spectrum of racemic 3a
Chiral HPLC spectrum of 3a
Chiral HPLC spectrum of racemic 3b S114 Chiral HPLC spectrum of 3b

Chiral HPLC spectrum of racemic 3c
Chiral HPLC spectrum of 3c S115

Chiral HPLC spectrum of racemic 3d
Chiral HPLC spectrum of 3d S116

Chiral HPLC spectrum of racemic 3e
Chiral HPLC spectrum of 3e S117

Chiral HPLC spectrum of racemic 3f
Chiral HPLC spectrum of 3f

Chiral HPLC spectrum of racemic 3i
Chiral HPLC spectrum of 3i S120

Chiral HPLC spectrum of racemic 3j
Chiral HPLC spectrum of 3j S121

Chiral HPLC spectrum of racemic 3k
Chiral HPLC spectrum of 3k S122

Chiral HPLC spectrum of racemic 3m
Chiral HPLC spectrum of 3m

Chiral HPLC spectrum of 3n
Chiral HPLC spectrum of 3n (After recrystallization)

Chiral HPLC spectrum of racemic 3p
Chiral HPLC spectrum of 3p S127

Chiral HPLC spectrum of racemic 3q
Chiral HPLC spectrum of 3q

Chiral HPLC spectrum of racemic 3t
Chiral HPLC spectrum of 3t