Translation starts with the assembly of the ribosome from its subunits, which requires the formation of intersubunit bridges. A combinatorial mutagenesis approach has now identified a number of the 16S rRNA residues involved in intersubunit bridging that are functionally important for the ribosome.
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Gao, N., Frank, J. A library of RNA bridges. Nat Chem Biol 2, 231–232 (2006). https://doi.org/10.1038/nchembio0506-231
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DOI: https://doi.org/10.1038/nchembio0506-231
