Notch signaling is an essential cell–cell communication pathway that influences numerous cell fate decisions during development. Structural and biochemical studies of a Notch–Jagged complex dramatically advance current understanding of ligand recognition, and reveal evidence of catch-bond behavior in the complex.
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References
Gordon, W.R. et al. Nat. Struct. Mol. Biol. 14, 295–300 (2007).
Moloney, D.J. et al. J. Biol. Chem. 275, 9604–9611 (2000).
Luca, V.C. et al. Science 355, 1320–1324 (2017).
Luca, V.C. et al. Science 347, 847–853 (2015).
Andrawes, M.B. et al. J. Biol. Chem. 288, 25477–25489 (2013).
Yamamoto, S. et al. Science 338, 1229–1232 (2012).
Kakuda, S. & Haltiwanger, R.S. Dev. Cell 40, 193–201 (2017).
Chillakuri, C.R. et al. Cell Rep. 5, 861–867 (2013).
Gordon, W.R. et al. Dev. Cell 33, 729–736 (2015).
Taylor, P. et al. Proc. Natl. Acad. Sci. USA 111, 7290–7295 (2014).
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Blacklow, S. Notch catches a Jagged edge. Nat Chem Biol 13, 570–571 (2017). https://doi.org/10.1038/nchembio.2379
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DOI: https://doi.org/10.1038/nchembio.2379
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