Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubicon in the immune response to Aspergillus fumigatus.
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Boyle, K., Randow, F. Rubicon swaps autophagy for LAP. Nat Cell Biol 17, 843–845 (2015). https://doi.org/10.1038/ncb3197
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DOI: https://doi.org/10.1038/ncb3197
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