Using in vitro reconstitution systems, three studies shed light on the interactions of Atg8 family proteins with cargo receptors and components of the basal autophagy machinery. The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during autophagosome formation.
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Johansen, T., Lamark, T. Selective autophagy goes exclusive. Nat Cell Biol 16, 395–397 (2014). https://doi.org/10.1038/ncb2961
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DOI: https://doi.org/10.1038/ncb2961
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