The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.
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Xie, J., Proud, C. Crosstalk between mTOR complexes. Nat Cell Biol 15, 1263–1265 (2013). https://doi.org/10.1038/ncb2877
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DOI: https://doi.org/10.1038/ncb2877
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