The cell cycle regulator p27Kip1 must be degraded to permit cell division. Degradation is moderate in G1 phase, but is enhanced in S-phase. Now, a novel ubiquitin ligase that can ubiquitinate p27 leading to its proteolysis after mitogen stimulation has been identified.
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Hengst, L. A second RING to destroy p27Kip1. Nat Cell Biol 6, 1153–1155 (2004). https://doi.org/10.1038/ncb1204-1153
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DOI: https://doi.org/10.1038/ncb1204-1153
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