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Aurora A moonlights in neurite extension

Nature Cell Biology volume 11, pages 1053–1054 (2009)Cite this article

Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCζ activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons.

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Figure 1: An aPKCζ–Aurora A–NDEL1 pathway is important for neurite outgrowth.

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Authors and Affiliations

  1. Department of Neurosciences, Gloria Kuo Lefkowitz and Joseph G. Gleeson are at the Neurogenetics Laboratory, Howard Hughes Medical Institute, University of California, CA 92093-0665, USA. jogleeson@ucsd.edu,

    Gloria Kuo Lefkowitz & Joseph G. Gleeson

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  1. Gloria Kuo Lefkowitz
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  2. Joseph G. Gleeson
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Lefkowitz, G., Gleeson, J. Aurora A moonlights in neurite extension. Nat Cell Biol 11, 1053–1054 (2009). https://doi.org/10.1038/ncb0909-1053

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