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Filling the Rab GAP

The human genome encodes at least 70 Rab GTPases and more than 50 putative Rab GTPase-activating proteins (GAPs). An elegant scheme to rapidly identify the Rab target for each of these GAPs has led to the identification of a potent Rab GAP for Rab5.

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Figure 1: A model for regulation of Rab5 by multiple GAPs.

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Pfeffer, S. Filling the Rab GAP. Nat Cell Biol 7, 856–857 (2005). https://doi.org/10.1038/ncb0905-856

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