Ubiquitin, best known as a degradation signal, is also a protein-sorting tag on endocytic cargoes and a regulatory switch on endocytic adaptor proteins. Parkin, a ubiquitin ligase whose mutations are associated with Parkinson's disease, has now been shown to control EGF-receptor internalization and Akt signalling by ubiquitination of the endocytic scaffold protein Eps15.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Di Fiore, P. P. & De Camilli, P. Cell 106, 1–4 (2001).
Haglund, K. & Dikic, I. EMBO J. 24, 3353–3359 (2005).
Hicke, L., Schubert, H.L. & Hill, C.P. Nature Rev. Mol. Cell Biol. 6, 610–621 (2005).
Polo, S. et al. Nature 416, 451–455 (2002).
Hoeller, D. et al. Nature Cell Biol. 8, 163–169 (2006).
van Delft, S., Govers, R., Strous, G. J., Verkleij, A.J. & van Bergen en Henegouwen, P. M. J. Biol. Chem. 272, 14013–14016 (1997).
Fallon, L. et al. Nature Cell Biol. 8, 834–842 (2006).
Chung, K. K. et al. Nature Med. 7, 1144–1150 (2001).
Huynh, D. P., Scoles, D. R., Nguyen, D. & Pulst, S. M. Hum. Mol. Genet. 12, 2587–2597 (2003).
Ren, Y., Zhao, J. & Feng, J. J. Neurosci. 23, 3316–3324 (2003).
Sigismund, S. et al. Proc. Natl Acad. Sci. USA 102, 2760–2765 (2005).
Iwakura, Y. et al. J. Neurochem. 93, 974–983 (2005).
Cookson, M. R. Annu. Rev. Biochem. 74, 29–52 (2005).
Sakata, E. et al. EMBO Rep. 3, 301–306 (2003).
Tsai, Y. C., Fishman, P. S., Thakor, N. V. & Oyler, G.A. J. Biol. Chem. 278, 22044–22055 (2003).
Dachsel, J. C. et al. FEBS Lett. 579, 3913–3919 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Husnjak, K., Dikic, I. EGFR trafficking: parkin' in a jam. Nat Cell Biol 8, 787–788 (2006). https://doi.org/10.1038/ncb0806-787
Issue Date:
DOI: https://doi.org/10.1038/ncb0806-787