Engulfment of pathogens by phagocytosis requires the coordination of actin assembly and progressive 'zippering' of pseudopodial membranes around the particle. Recent work shows that Myosin-X, which binds phosphatidylinositol-3-OH kinase (PI(3)K) products through its pleckstrin homology (PH) domains, is required for phagocytosis, thereby providing a molecular basis for the function of PI(3)K in pseudopod extension.
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Chavrier, P. May the force be with you: Myosin-X in phagocytosis. Nat Cell Biol 4, E169–E171 (2002). https://doi.org/10.1038/ncb0702-e169
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DOI: https://doi.org/10.1038/ncb0702-e169