Synaptic vesicle exocytosis, a finely tuned process that results in rapid neurotransmitter release, is still not fully understood. Studies in a simple reconstituted lipid bilayer system have now definitively demonstrated that synaptotagmin has a key role in calcium-mediated exocytosis and have also revealed additional aspects of exocytic fusion.
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Meldolesi, J., Chieregatti, E. Fusion has found its calcium sensor. Nat Cell Biol 6, 476–478 (2004). https://doi.org/10.1038/ncb0604-476
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DOI: https://doi.org/10.1038/ncb0604-476
