Many biological processes require the movement of cells in response to guidance cues. Small GTPases and phosphoinositides are key mediators of the underlying cytoskeletal rearrangements, and a new study establishes that the localization and activation of the phosphoinositide phosphatase PTEN at the rear of chemotaxing neutrophils is mediated by the small GTPase RhoA.
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Meili, R., Sasaki, A. & Firtel, R. Rho Rocks PTEN. Nat Cell Biol 7, 334–335 (2005). https://doi.org/10.1038/ncb0405-334
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DOI: https://doi.org/10.1038/ncb0405-334
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