Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Making brain proteomics true to type

Nature Biotechnology volume 36, pages 149–150 (2018)Cite this article

Subjects

Two independent but related strategies use unnatural amino acid incorporation to enable in vivo cell-type-specific proteomics in the mouse brain.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic overview of two novel approaches for cell-type-specific protein labeling in neurons of the mouse brain.

References

  1. Macosko, E.Z. et al. Cell 161, 1202–1214 (2015).

    Article  CAS  Google Scholar 

  2. Heiman, M. et al. Cell 135, 738–748 (2008).

    Article  CAS  Google Scholar 

  3. Alvarez-Castelao, B. et al. Nat. Biotechnol. 35, 1196–1201 (2017).

    Article  CAS  Google Scholar 

  4. Krogager, T.P. et al. Nat. Biotechnol. 36, 156–159 (2018).

    Article  CAS  Google Scholar 

  5. Kitchen, R.R., Rozowsky, J.S., Gerstein, M.B. & Nairn, A.C. Nat. Neurosci. 17, 1491–1499 (2014).

    Article  CAS  Google Scholar 

  6. Liao, L. et al. J. Biol. Chem. 279, 37061–37068 (2004).

    Article  CAS  Google Scholar 

  7. Drummond, E.S., Nayak, S., Ueberheide, B. & Wisniewski, T. Sci. Rep. 5, 15456 (2015).

    Article  CAS  Google Scholar 

  8. Dammer, E.B. et al. J. Proteome Res. 12, 3193–3206 (2013).

    Article  CAS  Google Scholar 

  9. Sharma, K. et al. Nat. Neurosci. 18, 1819–1831 (2015).

    Article  CAS  Google Scholar 

  10. Carlyle, B.C. et al. Nat. Neurosci. 20, 1787–1795 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. angus.nairn@yale.edu

Authors and Affiliations

  1. Rashaun S. Wilson and Angus C. Nairn are in the Department of Psychiatry, Yale School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut, USA.,

    Rashaun S Wilson & Angus C Nairn

Authors
  1. Rashaun S Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Angus C Nairn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Rashaun S Wilson or Angus C Nairn.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wilson, R., Nairn, A. Making brain proteomics true to type. Nat Biotechnol 36, 149–150 (2018). https://doi.org/10.1038/nbt.4077

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.4077

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research