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Stem cell signaling in newly diagnosed, antipsychotic-naive subjects with nonaffective psychosis

Molecular Psychiatry volume 14, pages 989–991 (2009)Cite this article

Widespread metabolic abnormalities have been described in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis, including a shorter telomere,1 abnormal glucose tolerance,2 an increase in the pro-inflammatory molecule interleukin-62 and an increased pulse pressure.1 Stromal-derived factor 1-alpha (SDF-1α), the major chemokine for adult stem cells (SCs), is involved in glucose regulation3 and is abnormal in diabetes.4 SDF1 is critical in homing, maintenance and mobilization of adult SCs.5 We tested the hypothesis that newly diagnosed, antipsychotic-naive patients with nonaffective psychosis would have a decreased concentration of circulating SDF-1α compared with control subjects.

The psychosis (N=24) and control (N=24) subjects were matched for race (Caucasian), gender, age, body mass index, smoking habit, cortisol blood levels, socioeconomic status and catchment area (Table 1). The two groups were matched before assaying SDF-1α concentrations. All subjects were interviewed using the Structured Clinical Interview for DSM-IV Axis I Disorders. Psychopathology was rated using the Positive and Negative Syndromes Scale (PANSS). Subjects in the psychosis group had a maximum lifetime antipsychotic exposure of 1 week and no antipsychotic use in the 30 days before the study, and had a diagnosis of nonaffective psychosis. Exclusion criteria for the control subjects included a history of psychosis or major depressive disorder. Additional general inclusion criteria were age from 18 to 64 years, no history of serious medical or neurological condition and not using any medication that impacts glucose tolerance. All subjects gave informed consent for participation in the study, which was conducted under the supervision of the local institutional review board.

Table 1 Characteristics of nonaffective psychosisa and control subjects
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Authors and Affiliations

  1. Department of Psychiatry, University of Cambridge, Cambridge, UK

    E Fernandez-Egea

  2. Cambridgeshire and Peterborough NHS Foundation Trust, Huntingdon, Cambridgeshire, UK

    E Fernandez-Egea

  3. Cancer Research UK, Li Ka Shing Centre, Cambridge Research Institute (CRI), Cambridge, UK

    A Bruna

  4. Department de Psiquiatria, Programa Esquizofrènia Clínic, Servei de Psiquiatria, Institut de Neurociències, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain

    E Fernandez-Egea, C Garcia-Rizo & M Bernardo

  5. Institut d'Investigacions Biomèdiques Agusti Pi i Sunyer (IDIBAPS), Barcelona, Spain

    M Bernardo

  6. Centro de Investigación Biom,

    C Garcia-Rizo & M Bernardo

  7. édica en Red de Salud Mental (CIBER-SAM), Spain

    C Garcia-Rizo & M Bernardo

  8. Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia

    B Kirkpatrick

Authors
  1. E Fernandez-Egea
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  2. A Bruna
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  3. C Garcia-Rizo
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  4. M Bernardo
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  5. B Kirkpatrick
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Correspondence to B Kirkpatrick.

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Fernandez-Egea, E., Bruna, A., Garcia-Rizo, C. et al. Stem cell signaling in newly diagnosed, antipsychotic-naive subjects with nonaffective psychosis. Mol Psychiatry 14, 989–991 (2009). https://doi.org/10.1038/mp.2009.45

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