ArticlePaired related homeobox protein 1 regulates PDGF-induced chemotaxis of hepatic stellate cells in liver fibrosis
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Supplementary Information accompanies the paper on the Laboratory Investigation website
Supplementary information The online version of this article (doi:10.1038/labinvest.2017.65) contains supplementary material, which is available to authorized users.
Jiazhi Liao and Dean Tian: These authors contributed equally to this work.
This study demonstrates that paired related homeobox protein 1 (Prrx1) acts as a critical downstream molecule in PDGF signaling pathway and plays a major role in the recruitment of PDGF-dependent hepatic stellate cells via modulation of matrix metalloproteinases 2 and 9. Additionally, knockdown of Prrx1 attenuates liver fibrosis in animal models.
© 2017 United States & Canadian Academy of Pathology.