Research ArticleA novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein
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Keywords
CD36
high-fat diet
inflammation
mice
NASH
oxidized low-density lipoprotein
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A murine model of non-alcoholic steatohepatitis (NASH) is established by the combination of a high-fat diet (HFD) and oxidized low-density lipoprotein (oxLDL). An increased oxidative state resulting from HFD-induced intracellular lipid peroxidation and oxLDL is the trigger for hepatic inflammation. CD36 expressed on hepatocytes and hepatic macrophages mediate the pathophysiology of NASH.
© 2012 United States & Canadian Academy of Pathology.