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Risks and predictors of mild diastolic dysfunction among middle-aged and aged women: a population-based cohort study

Journal of Human Hypertension volume 30, pages 335–340 (2016)Cite this article

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Abstract

We sought to determine the predictors of primary episodes of mild diastolic dysfunction (DD) in a cohort of women aged >45 years, who had >2 echocardiography from 2009 to 2012. Patients were excluded if they had prior diagnosis of coronary artery disease, heart failure, valvular heart disease or echocardiographic evidence of DD. Mild DD was defined as: left ventricular ejection fraction>50%, E/A ratio<0.75, and E/e’⩽8. Out of the total 758 subjects (age 64.15±7.24 years), 109 (14.3%) had developed mild DD, during a mean followup period of 3 years. Independent predictors of mild DD included: age (P<0.001), history of hypertension (P=0.022), body mass index (BMI) (P<0.001), total triglycerides (TG) (P=0.016), inter ventricular septal thickness (P=0.015) and brachial-ankle pulse wave velocity (baPWV) ⩾16 m s−1 (P<0.001). E/A ratio was inversely associated with age (r=−0.337, P<0.001), baPWV (r=−0.359, P<0.001), BMI (r=−0.290, P<0.001) and TG (r=−0.255, P<0.001). The Area Under roc Curve for a linear combination of age, BMI, baPWV and TG was 0.738 (95% confidence interval: 0.683–0.804, P<0.001), which was superior to any of the variables taken alone. In summary, many middle-aged or elderly women may develop mild DD within a relatively short period of 3 years. Several subclinical abnormalities and cardiovascular parameters were determined to contribute to the onset of DD.

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Acknowledgements

The study was carried out as a collaborative study supported by the residents’ Committee of Lujiazui Community, Shanghai; Center of Cardiology, Department of Ultrasonography and Department of Clinical Laboratory in Shanghai East Hospital. The authors express their sincere gratitude to all the staffs in this survey for their important contribution. Funding sources: The study was funded by scientific and technological development and innovation fund of government of Pudong New Area, Shanghai; Shanghai Municipal Commission of Health and Family Planning (No. 201440312); the Nature Science Foundation of China (No. 81001252, 81170325); Shanghai Municipal Health Bureau, China (No. 201440312).

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  1. Division of Preventive Medicine, Tongji University School of Medicine, Shanghai, China

    J Wu, S Y Yu, D Wo, M M Zhao, L J Zhang & J Li

  2. Key Laboratory of Arrhythmias of Ministry of Education of China, Tongji University, Shanghai, China

    J Wu & J Li

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Wu, J., Yu, S., Wo, D. et al. Risks and predictors of mild diastolic dysfunction among middle-aged and aged women: a population-based cohort study. J Hum Hypertens 30, 335–340 (2016). https://doi.org/10.1038/jhh.2015.85

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