15 years after a giant leap for cancer genomics

Cai, Sheng F.; Levine, Ross L.

doi:10.1038/d41586-023-03626-x

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15 years after a giant leap for cancer genomics

In 2008, the first comprehensive sequence of a cancer genome was reported, ushering in a new era of molecular diagnostic, prognostic and therapeutic advances informed by an essential framework to understand cancer’s complexities.

Sheng F. Cai
1. Sheng F. Cai is in the Department of Medicine, Leukemia Service, and the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
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Ross L. Levine
1. Ross L. Levine is in the Department of Medicine, Leukemia Service, and the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
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Efforts to understand the molecular underpinnings of cancer took a giant leap forward fifteen years ago, when Ley et al.¹ reported the first complete genome of a cancer — specifically, acute myeloid leukaemia (AML). Genomic data sets of this kind generated in the intervening years have revolutionized our knowledge about tumour biology.

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Nature 623, 920-921 (2023)

doi: https://doi.org/10.1038/d41586-023-03626-x

References

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Competing Interests

R.L.L is on the supervisory board of Qiagen and is a scientific adviser to Imago, Mission Bio, Kurome, Ajax, Auron, Prelude andC4 Therapeutics, each of which includes equity as compensation. He receives research support from Ajax, Zentalis and Abbvie. S.F.C. previously held equity interest in Imago Biosciences. None of these are related to the content of this paper. S.F.C. was a graduate student in the Ley laboratory from 2004 to 2009.

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[1] Ley, T. J. et al. Nature 456, 66–72 (2008).
Article PubMed Google Scholar

[2] Nowell, P. C. & Hungerford, D. A. Science 132, 1497 (1960).
Article Google Scholar

[3] Rowley, J. D. Nature 243, 290–293 (1973).
Article PubMed Google Scholar

[4] Druker, B. J. et al. Nature Med. 2, 561–566 (1996).
Article PubMed Google Scholar

[5] Druker, B. J. et al. N. Engl. J. Med. 344, 1031–1037 (2001).
Article PubMed Google Scholar

[6] Samuels, Y. et al. Science 304, 554 (2004).
Article PubMed Google Scholar

[7] Lynch, T. J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).
Article PubMed Google Scholar

[8] Paez, J. G. et al. Science 304, 1497–1500 (2004).
Article PubMed Google Scholar

[9] Miles, L. A. et al. Nature 587, 477–482 (2020).
Article PubMed Google Scholar

[10] Morita, K. et al. Nature Commun. 11, 5327 (2020).
Article PubMed Google Scholar

[11] Ding, L. et al. Nature 481, 506–510 (2012).
Article PubMed Google Scholar

[12] Wong, T. N. et al. Nature 518, 552–555 (2015).
Article PubMed Google Scholar

[13] Jongen-Lavrencic, M. et al. N. Engl. J. Med. 378, 1189–1199 (2018).
Article PubMed Google Scholar

[14] Klco, J. M. et al. JAMA 314, 811–822 (2015).
Article PubMed Google Scholar

[15] Mardis, E. R. et al. N. Engl. J. Med. 361, 1058–1066 (2009).
Article PubMed Google Scholar

[16] Parsons, D. W. et al. Science 321, 1807–1812 (2008).
Article PubMed Google Scholar

[17] Dang, L. et al. Nature 462, 739–744 (2009).
Article PubMed Google Scholar

[18] Mellinghoff, I. K. et al. N. Engl. J. Med. 389, 589–601 (2023).
Article PubMed Google Scholar

15 years after a giant leap for cancer genomics

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