Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • COMMENT

The potential of innovative trial design for efficiently evaluating repurposed drugs

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Nature Reviews Drug Discovery 22, 681-682 (2023)

doi: https://doi.org/10.1038/d41573-023-00129-2

Acknowledgements

J.M.S.W. is funded by a NIHR Research Professorship (NIHR301614).

References

  1. Pushpakom, S. et al. Drug repurposing: progress, challenges and recommendations. Nat. Rev. Drug Discov. 18, 41–58 (2019).

    Article  PubMed  Google Scholar 

  2. Tang, Y., Yang, K., Zhao, J., Liang, X. & Wang, J. Evidence of repurposing drugs and identifying contraindications from real world study in Parkinson’s disease. ACS Chem. Neurosci. 10, 954–963 (2019).

    Article  PubMed  Google Scholar 

  3. Woodcock, J. & LaVange, L. M. Master protocols to study multiple therapies, multiple diseases, or both. N. Engl. J. Med. 377, 62–70 (2017).

    Article  PubMed  Google Scholar 

  4. Zheng, H., Jaki, T. & Wason, J. M. S. Bayesian sample size determination using commensurate priors to leverage preexperimental data. Biometrics 79, 669–683 (2023).

    Article  PubMed  Google Scholar 

  5. Austin, C. P., Mount, B. A. & Colvis, C. M. Envisioning an actionable research agenda to facilitate repurposing of off-patent drugs. Nat. Rev. Drug Discov. 20, 723–724 (2021).

    Article  PubMed  Google Scholar 

Download references

Supplementary Information

  1. Supplementary information

Competing Interests

The authors declare no competing interests.

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Quick links