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Letters to the Editor

CXCL10 can be detected non-invasively from the skin of children with acute skin GvHD

Bone Marrow Transplantation volume 51, pages 1379–1381 (2016)Cite this article

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Acute GvHD is a significant complication of allogeneic hematopoietic stem cell transplantation (HCT) and carries a high rate of morbidity and mortality.1 Chemokines are known to influence the recruitment of activated donor T-lymphocytes to target organs.2 C-X-C motif chemokine 10 (also known as interferon-γ-inducible protein-10) has been previously reported to be elevated in the serum of adult allogeneic HCT recipients with acute skin GvHD.3 CXCL10 was also shown to be detected in the epidermis in skin biopsies from patients with acute skin GvHD, but not from gastrointestinal (GI) biopsies from patients with acute GI GvHD.3 Therefore, CXCL10 is thought to play a role in the pathogenesis of acute skin GvHD by recruiting activated T-lymphocytes to the skin.4

Studying target organ cytokines in children is challenging due to the invasive nature of skin biopsies, especially as acute GvHD is primarily a clinical diagnosis and biopsies are often unavailable.5 Recent studies in neonates demonstrated a novel methodology to detect skin cytokines non-invasively, making this an attractive approach in pediatric HCT recipients.6

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Acknowledgements

We would like to acknowledge the immense contribution of Dr Alexandra H Filipovich and Dr Marty O Visscher to the study design but were unfortunately unable to contribute and review the manuscript. We would like to acknowledge the patients, families and clinical staff at Cincinnati Children’s Hospital Medical Center.

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Authors and Affiliations

  1. Division of Bone Marrow Transplantation, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    P Khandelwal, K Smiley & S M Davies

  2. Global Biotechnology, The Procter & Gamble Co., Mason, OH, USA

    A M Fieno & R A Grant

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  1. P Khandelwal
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  2. K Smiley
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  3. A M Fieno
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  5. S M Davies
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Correspondence to P Khandelwal.

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Khandelwal, P., Smiley, K., Fieno, A. et al. CXCL10 can be detected non-invasively from the skin of children with acute skin GvHD. Bone Marrow Transplant 51, 1379–1381 (2016). https://doi.org/10.1038/bmt.2016.119

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