Abstract
Pulmonary cytolytic thrombi (PCT) is an uncommon complication after hematopoietic cell transplantation. Although the pathogenesis is unknown, patients typically respond to systemic corticosteroid treatment. Considering corticosteroids may impair GVL reactions, we reviewed the records of 324 pediatric patients who received a transplant for leukemia and compared the outcomes of those with PCT (n=14) to those without PCT (n=310). PCT patients had a significantly more acute GVHD (aGVHD) and chronic GVHD (cGVHD). Though 3-year non-relapse mortality and OS were similar, there was significantly less relapse in patients with PCT compared to those without PCT (0 vs 28%, P=0.02), regardless of the presence or absence of aGVHD. In multivariate analysis, grade II–IV aGVHD (P=0.02), cGVHD (P=0.01) and development of PCT (P<0.01) were independently associated with less relapse. These data suggest that patients with PCT are at greater risk for GVHD, but at lower risk of leukemia relapse.
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References
Gulbahce H, Manivel J, Jessurun J . Pulmonary cytolytic thrombi: a previously unrecognized complication of bone marrow transplantation. Am J Surg Pathol 2000; 24: 1147–1152.
Woodard J, Gulbahce E, Shreve M, Steiner M, Peters C, Hite S et al. Pulmonary cytolytic thrombi: a newly recognized complication of stem cell transplantation. Bone Marrow Transplant 2000; 25: 293–300.
Peters A, Manivel J, Dolan M, Gulbahce H, Baker K, Verneris M . Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description. Biol Blood Marrow Transplant 2005; 11: 484–485.
Morales I, Anderson P, Tazelaar H, Wylam M . Pulmonary cytolytic thrombi: unusual complication of hematopoietic stem cell transplantation. J Pediatr Hematol Oncol 2003; 25: 89–92.
Smith A, Baker K, Defor T, Verneris M, Wagner J, Macmillan M . Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donors. Biol Blood Marrow Transplant 2009; 15: 1086–1093.
Verneris M, Brunstein C, Barker J, Macmillan M, Defor T, McKenna D et al. Relapse risk after umbilical cord blood transplantation: enhanced graft versus leukemia effect in recipients of two units. Blood 2009; 114: 4293–4299.
Arora M, Nagaraj S, Wagner J, Barker J, Brunstein C, Burns L et al. Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation (HSCT): higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB). Biol Blood Marrow Transplant 2007; 13: 1145–1152.
MacMillan ML, Weisdorf DJ, Wagner JE, DeFor TE, Burns LJ, Ramsay NK et al. Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems. Biol Blood Marrow Transplant 2002; 8: 387–394.
Horwitz ME, Sullivan KM . Chronic graft-versus-host disease. Blood Rev 2006; 20: 15–27.
Lin DY . Non-parametric inference for cumulative incidence functions in competing risks studies. Stat Med 1997; 16: 901–910.
Kaplan EL, Meier P . Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457–481.
Fine JP, Gray RJ . A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999; 94: 496–509.
Cox DR . Regression models and life tables. J R Stat Soc B 1972; 34: 187–220.
Gulbahce H, Pambuccian S, Jessurun J, Woodard P, Steiner M, Manivel J et al. Pulmonary nodular lesions in bone marrow transplant recipients: impact of histologic diagnosis on patient management and prognosis. Am J Clin Pathol 2004; 121: 205–210.
Valcárcel D, Martino R, Piñana J, Sierra J . Allogeneic stem cell transplantation after reduced-intensity conditioning for acute myeloid leukaemia: impact of chronic graft-versus-host disease. Curr Opin Oncol 2009; 21 (Suppl 1): S35–S37.
Weisdorf D . GVHD the nuts and bolts. Hematology Am Soc Hematol Educ Program 2007, 62–67.
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This research was in part supported by the Children's Cancer Research Fund.
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Smith, A., Gulbahce, E., Burke, M. et al. Lower leukemia relapse in pediatric patients with pulmonary cytolytic thrombi following allogeneic transplant. Bone Marrow Transplant 46, 368–371 (2011). https://doi.org/10.1038/bmt.2010.119
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DOI: https://doi.org/10.1038/bmt.2010.119
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