Abstract
Inocula of cultured sheep cells that had been transformed with FeSV were injected into the legs of sheep so that the changes in the cellular and humoral composition of the efferent lymph from the regional node could be studied throughout the immune responses. The times at which immunoblasts and specific antibodies appeared in the lymph were similar to those recorded during responses to conventional antigens. The antiboides were mainly 7S, G1 immunoglobulins directed against virion antigens on the membranes of the transformed cells.
Larger doses of transformed cells were injected into 12 sheep so that 4 of them developed locally invasive, poorly differentiated fibrosarcomata. Two tumours regressed spontaneously; 2 grew progressively and one of these gave rise to regional metastases. The progressive tumours were not infiltrated with host cells and grew in the presence of high titres of antibody. The tumours that regressed were infiltrated heavily with round cells and detectable antibody was low or absent.
The flow and composition of peripheral lymph coming from the tumours showed that the failure of the host to control tumour growth could not be accounted for by a failure of the tumour capillaries to allow the normal transmigration of host cells and humoral factors.
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Hall, J., Scollay, R., Birbeck, M. et al. Studies on FeSV induced sarcomata in sheep with particular reference to the regional lymphatic system. Br J Cancer 32, 639–659 (1975). https://doi.org/10.1038/bjc.1975.275
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DOI: https://doi.org/10.1038/bjc.1975.275