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Effects of Interferon on Leukaemia Virus Activation in Graft versus Host Disease

Nature New Biology volume 244, pages 102–103 (1973)Cite this article

Abstract

MALIGNANT lymphomas are relatively common in patients with certain immunological disorders such as Sjogren's syndrome, and in recipients of organ transplants1,2. Although no oncogenic viruses have been definitively associated with these human neoplasms, we have recently shown in the mouse that analogous immune dyscrasias are associated with activation of leukaemia viruses3–5. In graft versus host (GvH) disease, these viruses become apparent soon after injection of F1 animals with parental lymphoid cells, and current evidence indicates that they are causally related to the malignant lymphomas that subsequently develop in these animals3,6. More recently, we have demonstrated similar activation after murine skin homograft transplantation4 and in the mixed lymphocyte reaction in vitro5.

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References

  1. Cummings, N. A., Schall, G. L., Asofsky, R., Anderson, L. G., and Talal, N., Ann. Int. Med., 75, 937 (1971).

    Article  CAS  Google Scholar 

  2. Penn, I., and Startzl, T. E., Transplantation, 14, 407 (1972).

    Article  CAS  Google Scholar 

  3. Hirsch, M. S., Black, P. H., Tracy, G. S., Leibowitz, S., and Schwartz, R. S., Proc. US Nat. Acad. Sci., 67, 1914 (1970).

    Article  CAS  Google Scholar 

  4. Hirsch, M. S., Ellis, D. A., Black, P. H., Wood, M. L., and Monaco, A. P., Science, 180, 500 (1973).

    Article  CAS  Google Scholar 

  5. Hirsch, M. S., Phillips, S. M., Solnik, C., Black, P. H., Schwartz, R. S., and Carpenter, C. B., Proc. US Nat. Acad. Sci., 69, 1069 (1972).

    Article  CAS  Google Scholar 

  6. Armstrong, M. Y. K., Black, F. L., and Richards, F. F., Nature New Biology, 235, 153 (1972).

    Article  CAS  Google Scholar 

  7. Wheelock, E. F., and Larke, R. P. B., Proc. Soc. Exp. Biol. Med., 127, 230 (1968).

    Article  CAS  Google Scholar 

  8. Gressor, I., Berman, L., De-Thé, G., et al., J. Nat. Cancer Inst., 41, 505 (1968).

    Google Scholar 

  9. Sarma, P. S., Shiv, G., Baron, S., and Huebner, R. J., Nature, 223, 845 (1969).

    Article  CAS  Google Scholar 

  10. Rhim, J. S., and Huebner, R. J., Proc. Soc. Exp. Biol. Med., 136, 524 (1971).

    Article  CAS  Google Scholar 

  11. Oie, H., Gazdar, A. F., and Buckler, C. E., J. Gen. Virol., 17, 107 (1972).

    Article  CAS  Google Scholar 

  12. Klement, V., Rowe, W. P., Hartley, J. W., and Pugh, W. E., Proc. US Nat. Acad. Sci., 63, 753 (1969).

    Article  CAS  Google Scholar 

  13. Lindenmann, J., and Gifford, G. E., Virology, 19, 302 (1963).

    Article  CAS  Google Scholar 

  14. Armstrong, M. Y. K., Schwartz, R. S., and Beldotti, L., Transplantation, 6, 1380 (1967).

    Article  Google Scholar 

  15. Lindahl-Magnuson, P., Leary, P., and Gresser, I., Nature New Biology, 237, 120 (1972).

    Article  Google Scholar 

  16. Dean, J. H., Wallet, W. C., Gauntt, C., and Lucas, D. O., Proc. Amer. Soc. Microbiol. (in the press).

Download references

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Authors and Affiliations

  1. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, 02114

    M. S. HIRSCH, D. A. ELLIS, M. R. PROFFITT & P. H. BLACK

  2. Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland, 20014

    M. A. CHIRIGOS

Authors
  1. M. S. HIRSCH
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  2. D. A. ELLIS
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  3. M. R. PROFFITT
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  4. P. H. BLACK
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  5. M. A. CHIRIGOS
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HIRSCH, M., ELLIS, D., PROFFITT, M. et al. Effects of Interferon on Leukaemia Virus Activation in Graft versus Host Disease. Nature New Biology 244, 102–103 (1973). https://doi.org/10.1038/newbio244102a0

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