Signaling via phosphorylation-regulated protein-protein interactions often involves flexible or unstructured proteins. Detailed biophysical and computational studies on one such interaction reveal a marvelously intricate, temporally regulated, multistep conduit for signal transduction in the cell cycle.
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References
Galea, C.A. et al. J. Mol. Biol. 376, 827–838 (2007).
Grimmler, M. et al. Cell 128, 269–280 (2007).
Chu, I. et al. Cell 128, 281–294 (2007).
Lacy, E.R. et al. Nat. Struct. Mol. Biol. 11, 358–364 (2004).
Russo, A.A. et al. Nature 382, 325–331 (1996).
Oldfield, C.J. et al. BMC Genomics 9, S1 (2008).
Xie, H. et al. J. Proteome Res. 6, 1917–1932 (2007).
Iakoucheva, L. et al. Nucleic Acids Res. 32, 1037–1049 (2004).
Wu, G. et al. Mol. Cell 11, 1445–1456 (2003).
Dunker, A.K. et al. Pac. Symp. Biocomput. 4, 473–484 (1998).
Kriwacki, R.W. et al. Proc. Natl. Acad. Sci. USA 93, 11504–11509 (1996).
Schulz, G. in Molecular Mechanisms of Biological Recognition (ed. Balaban, M.) 79–94 (Elsevier/North Holland Biomedical Press, New York, 1979).
Carella, A.M. & Lerma, E. Curr. Stem Cell Res. Ther. 2, 249–251 (2007).
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Dunker, A., Uversky, V. Signal transduction via unstructured protein conduits. Nat Chem Biol 4, 229–230 (2008). https://doi.org/10.1038/nchembio0408-229
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DOI: https://doi.org/10.1038/nchembio0408-229
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