Abstract
Age-related macular degeneration (ARMD) is the most common cause of visual morbidity in the aged in the Western world. The aetiology of ARMD is unknown. Although clinicians have noted that ARMD demonstrates a familial tendency, the question regarding the role of hereditary factors in ARMD remains unanswered. The aims of this study were to assess the level of genetic input into ARMD and to assess the mode of inheritance of the disease. Fifty affected patients and 50 age- and sex-matched controls and their immediate families were invited to take part in the study. Thirty-six patients, controls and their families were studied. Eighty-one siblings of affected patients and 78 control siblings were available. Twenty of the 81 affected siblings were found to suffer from ARMD. In contrast only 1 of 78 control siblings had ARMD. This was statistically significant. The results confirm that hereditary factors are important in the aetiology of ARMD.
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Aclimandos WA, Galloway NR . Blindness in the city of Nottingham (1980-1985). Eye 1988;2:431–4.
Pizzarello LD . The dimensions of the problem of eye disease among the elderly. Ophthalmology 1987;94:1191–5.
Bradley AE . Dystrophy of the macula. Am J Ophthalmol 1966;61:1–24.
Gass JDM . Serous retinal pigment epithelial detachment and degeneration. Arch Ophthalmol 1973;90:206–17.
Hyman LG, Lilienfeld AM, Ferris FL III, Fine SL . Senile macular degeneration: a case-control study. Am J Epidemiol 1983;118:213–27.
Piguet B, Wells JA, Palmvang IB, Wormald R, Chisholm IH, Bird AC . Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment. Br J Ophthalmol 1993;77:400–3.
Leibowitz HM, Kreuger DE, Maunder LR, et al The Framingham Eye Study Monograph. Surv Ophthalmol 1980;24 (suppl):428–57.
Sperduto RD, Hiller R, Seigel D . Lens opacities and senile maculopathy. Arch Ophthalmol 1981;99:1004–8.
Gregor A, Bird AC, Chisholm IH . Senile disciform macular degeneration in the second eye. Br J Ophthalmol 1977;61:141–7.
Goldberg J, Flowerdew E, Smith E, Brody JA, Tso MOM . Factors associated with age-related macular degeneration. Am J Epidemiol 1988; 128:700–10.
Fleiss JL . Statistical methods for rates and proportions. New York: John Wiley, 1973:46.
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Silvestri, G., Johnston, P. & Hughes, A. Is genetic predisposition an important risk factor in age-related macular degeneration?. Eye 8, 564–568 (1994). https://doi.org/10.1038/eye.1994.138
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DOI: https://doi.org/10.1038/eye.1994.138
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