Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

Kun Jiang et al.

Nature Immunol. 1, 419– 425 (2000).

In the November 2000 issue of Nature Immunology Figure 1a and b were printed incorrectly, although the online version and PDF are correct. Below are the correct figure parts, along with the relevant part of the legend.

Figure 1. Suppression of NK92 lytic function by PI3K inhibitors. Blockade of (a) perforin and (b) granzyme B movement by inhibition of PI3K or MEK. NK92 cells pretreated with DMSO, PD98059 (PD, 50 μM), LY294002 (LY, 50 μM) or wortmannin (WM, 50 nM) were mixed with equal numbers of Raji tumor cells for 5 min at 37 °C. The cytospun cells were then stained with (a) FITC–anti-perforin and TRITC–anti-IgM (b) or with FITC–anti-granzyme B and TRITC–anti-IgM.