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Fraternal twins: AQP1 and GlpF

The electron and X-ray crystallographic structures of AQP1 and GlpF, respectively, provide insights into the mechanisms of how water and small solutes such as glycerol selectively traverse lipid bilayers.

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Figure 1: Topology of aquaporin.
Figure 2: Aquaporin structure in a nutshell (adapted from ref. 1).
Figure 3: Mechanisms of water and glycerol transport.

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Acknowledgements

I would like to thank K. Murata for providing templates for Fig. 2, and F. Sigworth, A. Cheng and M. Yeager for comments.

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Unger, V. Fraternal twins: AQP1 and GlpF. Nat Struct Mol Biol 7, 1082–1084 (2000). https://doi.org/10.1038/81914

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