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Reply to 'LMP2 expression and proteasome activity in NOD mice'

Nature Medicine volume 6, pages 1065–1066 (2000)Cite this article

Hayashi et al. reply

In our paper, we described developmentally expressed defects in splenocytes and macrophages in NF-κB activation and LMP2 expression in the NOD mouse4. These defects parallel disease expression, which occurs in 30% of males and 70% of females by 30 weeks of age13, and we emphasized that such abnormalities are never seen early in life. In contrast, we and others have reported normal or augmented proteasome and NF-κB activity in target tissue in autoimmune mice4,14. Thus, phenotypic derangements in proteasome and NF-κB depend on gender, age, tissue and disease course in individual NOD mice.

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Figure 1: Effects of TNF-α on the survival of spleen cells derived from 7-week-old C57Bl/6, NOD and LMP2−/− mice.

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Author notes

  1. Takuma Hayashi and Shohta Kodama: T.H. & S.K. contributed equally to this work.

Authors and Affiliations

  1. Immunobiology Laboratory, Massachusetts General Hospital-East,and Harvard Medical School, Building 149, 13th Street, CNY-3601, Charlestown, 02129 , Massachusetts, USA

    Takuma Hayashi, Shohta Kodama & Denise L. Faustman

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  1. Takuma Hayashi
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Correspondence to Denise L. Faustman.

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Hayashi, T., Kodama, S. & Faustman, D. Reply to 'LMP2 expression and proteasome activity in NOD mice' . Nat Med 6, 1065–1066 (2000). https://doi.org/10.1038/80353

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