Abstract
INSULIN-DEPENDENT diabetes mellitus (IDDM) is a polygenic disease caused by autoimmune destruction of insulin-producing β cells in the islets of Langerhans1,2. Its onset is preceded by a long and variable period in which lymphoid cells infiltrate the pancreas but first remain outside the islets (peri-insulitis) before invading them (insulitis)3–7. Among susceptibility loci, only the major histocompatibility complex (MHC) has been clearly assigned8–12. Genetic study of the nonobese diabetic (NOD) mouse model for insulin-dependent diabetes mellitus has revealed genetic linkage of insulitis and of early onset diabetes with two non-MHC loci mapping to chromosome 3 and 11 respectively13. Here we report a close association of periinsulitis with a third non-MHC locus mapping to chromosome 1. Successive stages in the progression of diabetic disease thus appear to be controlled by distinct genes or sets of genes.
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Garchon, HJ., Bedossa, P., Eloy, L. et al. Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice. Nature 353, 260–262 (1991). https://doi.org/10.1038/353260a0
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DOI: https://doi.org/10.1038/353260a0
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