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PX domains: attracted by phosphoinositides

Nature Cell Biology volume 3, pages E179–E181 (2001)Cite this article

Phosphoinositides recruit proteins to distinct intracellular membranes. Now, the Phox homology (PX) domain, an evolutionarily conserved protein domain whose function has so far been elusive, has been demonstrated to bind phosphoinositides. The interactions of PX-domain-containing proteins with specific phosphoinositides are critical for cellular activities such as microbial killing and membrane trafficking.

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Figure 1: Schematic view of phosphatidylinositol (PI) and selected phosphoinositides.
Figure 2: Proposed functions of PX-domain proteins.

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Authors and Affiliations

  1. Department of Biochemistry, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway

    Anne Simonsen & Harald Stenmark

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  1. Anne Simonsen
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  2. Harald Stenmark
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Simonsen, A., Stenmark, H. PX domains: attracted by phosphoinositides. Nat Cell Biol 3, E179–E181 (2001). https://doi.org/10.1038/35087112

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