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Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

Nature volume 344, pages 160–162 (1990)Cite this article

Abstract

ATHEROSCLEROSIS in animals and humans is associated with an unresponsiveness of arteries and arterioles to endothelium-dependent vasodilators1–3—agents acting on smooth muscle indirectly by stimulating the release from endothelial cells of a vasodilator principle (endothelium-derived relaxing factor)4. Altered vasomotor regulation in atherosclerosis could partly reflect an injurious action of abnormal lipoproteins on endothelium5,6. Recently, 'cell-modified' or 'oxidized' low-density lipoprotein (EC-LDL) has received increasing attention because of its potential cytotoxic and atherogenic properties7. We report here that arteries exposed to EC-LDL in vitro show an endothelium-dependent vasoregulatory impairment closely resembling that of atherosclerotic arteries. Our results indicate that transfer of lysolecithin from EC-LDL to endothelial membranes produces a selective unresponsiveness to receptor-regulated endothelium-dependent vasodilators.

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Author notes

  1. Philip D. Henry: To whom correspondence should be addressed.

Authors and Affiliations

  1. Departments of Medicine, Baylor College of Medicine, Houston, Texas, 77030, USA

    Kiyotaka Kugiyama, Scott A. Kerns, Robert Roberts & Philip D. Henry

  2. Departments of Biochemistry, Baylor College of Medicine, Houston, Texas, 77030, USA

    Joel D. Morrisett

  3. Departments of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Philip D. Henry

Authors
  1. Kiyotaka Kugiyama
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  3. Joel D. Morrisett
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  4. Robert Roberts
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  5. Philip D. Henry
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Kugiyama, K., Kerns, S., Morrisett, J. et al. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature 344, 160–162 (1990). https://doi.org/10.1038/344160a0

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