Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases

Nature volume 328, pages 170–172 (1987)Cite this article

Abstract

Using DNA transfection analysis1 on NIH3T3 cells2, activated human oncogenes have been isolated from a variety of fresh solid tumours3. Thyroid neoplasias show a wide range of lesions varying from slowly progressive well-differentiated tumours to anaplastic highly malignant neoplasms4. Therefore they represent an attractive model to investigate the role of oncogene activation in different stages of the neoplastic state. Here we report the detection of transforming activity in DNAs extracted from five thyroid papillary carcinomas and two of their respective lymph-nodal metastases.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. 1. Graham, F. L. & van der Eb, A. /. Virol. 52, 456–467 (1973). 2. lainchill, J. L., Aaronson, S. A. & Todaro, G. S. / Virol. 4, 549–553 (1960). 3. Pulciani, S. el al. Nature 300, 539–542 (1982). 4. Heitz, P., Moser, H., Staub, J. J. Cancer 37, 2329–2337 (1976). 5. Jelinek, W. R. el al Proc. natn. Acad. Sci. U.S.A. 77, 1398–1402 (1980). 6. Cooper, C. S. el al Nature 311, 671–673 (1983). 7. Fasano, O., Birnbaum, D., Edlund, L., Fogh, J. & Wigler, M. Molec. cell. Bio/. 4,1695–1705 (1984). 8. Padua, R. A., Barrass, N. & Currie, G. A. Nature 311, 671–673 (1984). 9. Martin-Zanca, D., Hughes, S. H. & Barbacid, M. Nature 319, 743–748 (1986). 10. Takahashi, M., Ritz, J. & Cooper, G. M. Cell 42, 581–588 (1985). 11. Schechter, A. L. el al Nature 312, 513–516 (1984). 12. Eva, A. & Aaronson, S. A. Nature 316, 273–275 (1985). 13. Turrin, A., Pilotti, S. & Basso-Ricci, S. Int. J. Radial. Oncol. Biol. Phys. 11,2149–2154 (1985).

Download references

Author information

Authors and Affiliations

  1. Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centre di Endocrinologia ed Oncologia Sperimentale del CNR, II Facoltà di Medicina e Chirurgia, Università di Napoli, Via S. Pansini 5, 80131, Naples, Italy

    A. Fusco, M. Grieco, M. Santoro, M. T. Berlingieri & G. Vecchio

  2. Divisione di Anatomia Patologica e Citologia, Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy

    S. Pilotti

  3. Divisione di Oncologia Sperimentale, Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy

    M. A. Pierotti & G. Della Porta

Authors
  1. A. Fusco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Grieco
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Santoro
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. T. Berlingieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Pilotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. A. Pierotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. Della Porta
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G. Vecchio
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fusco, A., Grieco, M., Santoro, M. et al. A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. Nature 328, 170–172 (1987). https://doi.org/10.1038/328170a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/328170a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing