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Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

Nature volume 315, pages 382–385 (1985)Cite this article

Abstract

Induction of mammary carcinomas in rats by a single exposure to a carcinogen during sexual development often involves malignant activation of the Ha-ras-1 locus. Each of the Ha-ras-1 oncogenes present in tumours induced by N-nitroso-N-methylurea, but not in those induced by 7,12-dimethylbenz(a)anthracene, became activated by the same G → A transition, the type of mutation induced by N-nitroso-N-methylurea. These results are consistent with the notion that Ha-ras-1 oncogenes are directly activated by the carcinogen during initiation of neoplasia.

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Authors and Affiliations

  1. Developmental Oncology Section, Basic Research Program, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Helmut Zarbl, Saraswati Sukumar, Anne V. Arthur, Dionisio Martin-Zanca & Mariano Barbacid

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  1. Helmut Zarbl
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  2. Saraswati Sukumar
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  3. Anne V. Arthur
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  4. Dionisio Martin-Zanca
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  5. Mariano Barbacid
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Zarbl, H., Sukumar, S., Arthur, A. et al. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315, 382–385 (1985). https://doi.org/10.1038/315382a0

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