Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Role of DNA replication in the repression of silent mating type loci in yeast

Nature volume 312, pages 247–251 (1984)Cite this article

Abstract

A putative origin of DNA replication is associated with the DNA sequences necessary for the repression of silent mating type loci in yeast. These sequences lie about a kilobase away from the affected promoters, so the repression must act at a distance. We show here that DNA replication is required for the onset of repression.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Astell, C. R. et al. Cell 27, 15–23 (1981).

    Article  CAS  Google Scholar 

  2. Nasmyth, K. A., Tatchell, K., Hall, B. D., Astell, C. R. & Smith, M. Nature 289, 244–250 (1981).

    Article  ADS  CAS  Google Scholar 

  3. Hawthorne, D. C. Abstr. Proc. 11th int. Congr. Genet. 7, 34–35 (1963).

    Google Scholar 

  4. Herskowitz, I. & Oshima, Y. in The Yeast Saccharomyces cerevisiae (eds Strathern, J. N., Jones, E. W. & Broach, J.) 181–211 (Cold Spring Harbor Laboratory, New York, 1981).

    Google Scholar 

  5. Klar, A. J. S., Strathern, J. N., Broach, J. B. & Hicks, J. B. Nature 289, 239–244 (1981).

    Article  ADS  CAS  Google Scholar 

  6. Abraham, J. et al. Cold Spring Harb. Symp. quant. Biol. 47, 989–997 (1983).

    Article  Google Scholar 

  7. Haber, J. E. & George, J. P. Genetics 93, 13–35 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Klar, A. J. S., Fogel, S. & Macleod, K. Genetics 93, 37–50 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Rine, J., Strathern, J. N., Hicks, J. B. & Herskowitz, I. Genetics 93, 877–901 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Rine, J. O., thesis, Univ. Oregon (1979).

  11. Banerji, T., Rusconi, S. & Schaffner, W. Cell 27, 299–308 (1981).

    Article  CAS  Google Scholar 

  12. Abraham, J., Nasmyth, K. A., Strathern, J. N., Klar, A. J. S. & Hicks, J. B. J. molec. Biol. 176, 307–331 (1984).

    Article  CAS  Google Scholar 

  13. Stinchcomb, D. T., Struhl, K. & Davies, R. W. Nature 282, 39–43 (1979).

    Article  ADS  CAS  Google Scholar 

  14. Beach, D., Piper, M. & Shall, S. Nature 284, 185–187 (1980).

    Article  ADS  CAS  Google Scholar 

  15. Chan, C. S. M. & Tye, B.-K. Proc. natn. Acad. Sci. U.S.A. 77, 6329–6333 (1980).

    Article  ADS  CAS  Google Scholar 

  16. Newlon, C. S. & Burke, W. in Mechanistic Studies of DNA Replication and Genetic Recombination Vol. 19 (eds Alberts, B. & Fox, C. F.) 339–409 (Academic, New York, 1980).

    Google Scholar 

  17. Celniker, S. E. & Campbell, J. L. Cell 31, 201–213 (1982).

    Article  CAS  Google Scholar 

  18. Miller, A. M. EMBO J, 3, 1061–1065 (1984).

    Article  CAS  Google Scholar 

  19. Thorner, J. in The Yeast Saccharomyces cerevisiae (eds Strathern, J. N., Jones, E. W. & Broach, J.) 143–180 (Cold Spring Harbor Laboratory, New York, 1981).

    Google Scholar 

  20. Hartwell, L. H. J. molec. Biol. 104, 803–817 (1976).

    Article  CAS  Google Scholar 

  21. Quinlan, R. A., Pogson, C. I. & Gull, K. J. Cell Sci. 46, 341–352 (1980).

    CAS  PubMed  Google Scholar 

  22. Kilmartin, J. V. Biochemistry 20, 3629–3633 (1981).

    Article  CAS  Google Scholar 

  23. Hereford, L. & Hartwell, L. H. J. molec. Biol. 84, 445–461 (1974).

    Article  CAS  Google Scholar 

  24. Gilbert, W. & Muller-Hill, B. in The Lactose Operon (eds Beckwith, J. R. & Zipser, D.) 93–109 (Cold Spring Harbor Laboratory, New York, 1970).

    Google Scholar 

  25. Johnson, A. D. et al. Nature 294, 217–223 (1981).

    Article  ADS  CAS  Google Scholar 

  26. Salstrom, J. S. & Szybalski, W. J. molec. Biol. 124, 195–221 (1978).

    Article  CAS  Google Scholar 

  27. de Crombrugghe, B., Mudryj, M., DiLauro, R. & Gottesman, M. Cell 18, 1145–1151 (1979).

    Article  CAS  Google Scholar 

  28. Alberts, B., Worcel, A. & Weintraub, H. in The Organization and Expression of the Eukaryotic Genome (eds Bradbury, E. M. & Javaherian, K.) 165–191 (Academic, New York, 1977).

    Google Scholar 

  29. Contreras, R., Gheysen, D., Knowland, J., van de Voode, A. & Fiers, W. Nature 300, 500–505 (1982).

    Article  ADS  CAS  Google Scholar 

  30. Keller, J. M. & Alwine, J. C. Cell 36, 381–389 (1984).

    Article  CAS  Google Scholar 

  31. Geiduschek, E. P., Elliott, T. & Kassavetis, G. A. in Bacteriophage T4 (eds Mathews, C. K., Kutter, E. M., Mosig, G. & Berget, P. B.) 189–192 (Am. Soc. Microbiol., Washington, DC, 1980).

    Google Scholar 

  32. Elliott, T. & Geiduschek, E. P. Cell 36, 211–219 (1984).

    Article  CAS  Google Scholar 

  33. Thomas, G. P. & Mathews, M. B. Cell 22, 523–533 (1980).

    Article  CAS  Google Scholar 

  34. Hartwell, L. J. Cell Biol. 85, 811–822 (1980).

    Article  CAS  Google Scholar 

  35. Reed, S. I. Genetics 95, 561–577 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Nasmyth, K. A. Nature 302, 670–676 (1983).

    Article  ADS  CAS  Google Scholar 

  37. Bucking-Throm, E., Duntze, W., Hartwell, L. H. & Manney, T. R. Expl Cell Res. 76, 99–110 (1973).

    Article  CAS  Google Scholar 

  38. Hereford, L., Bromley, S. & Osley, M. A. Cell 30, 305–310 (1982).

    Article  CAS  Google Scholar 

  39. Tatchell, K., Nasmyth, K. A., Hall, B. D., Astell, C. R. & Smith, M. Cell 27, 25–35 (1981).

    Article  CAS  Google Scholar 

  40. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Allan M. Miller & Kim A. Nasmyth

Authors
  1. Allan M. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kim A. Nasmyth
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miller, A., Nasmyth, K. Role of DNA replication in the repression of silent mating type loci in yeast. Nature 312, 247–251 (1984). https://doi.org/10.1038/312247a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/312247a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing