Abstract
Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis virus (AEV). In all, the peptides contain 83 amino acid residues, 74 of which are shared with v-erb-B. The AEV progenitor may have acquired the cellular gene sequences of a truncated EGF receptor (or closely related protein) lacking the external EGF-binding domain but retaining the transmembrane domain and a domain involved in stimulating cell proliferation. Transformation of cells by AEV may result, in part, from the inappropriate acquisition of a truncated EGF receptor from the c-erb-B gene.
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Guroff, G. (ed.) Growth and Maturation Factors (Wiley, New York, 1983).
Cohen, S. J. biol. Chem. 237, 1555–1562 (1962).
Ross, R. in Tissue Growth Factors (ed. Baserga, R.) 133–159 (Springer, Berlin, 1981).
Rozengurt, E. Molec. Biol. Med. 1, 169–181 (1983).
James, R. & Bradshaw, R. A. A. Rev. Biochem. (in the press).
Sporn, M. B. & Todaro, G. J. New Engl. J. Med. 303, 878–880, (1980).
Waterfield, M. D. et al. Nature 304, 35–39 (1983).
Doolittle, R. F. et al. Science 221, 275–277 (1983).
Robbins, K. C., Antoniades, H. N., Devare, S. G., Hunkapiller, M. W. & Aaronson, S. A. Nature 305, 605–608 (1983).
Deuel, T. F., Huang, J. S., Huang, S. S., Stroobant, P. & Waterfield, M. D. Science 221, 1348–1350 (1983).
Dulak, N. C. & Temin, H. M. J. cell. Physiol. 81, 161–170 (1973).
De Larco, J. E. & Todaro, G. J. Nature 272, 356–358 (1978).
Burk, R. R. Expl Cell Res. 101, 193–298 (1976).
Bourne, H. & Rozengurt, E. Proc. natn. Acad. Sci. U.S.A. 73, 4555–4559 (1976).
De Larco, J. E. & Todaro, G. J. Proc. natn. Acad. Sci. U.S.A. 75, 4001–4005 (1978).
Roberts, A. B., Frolik, C. A., Anzano, M. A. & Sporn, M. B. Fedn Proc. 42, 2621–2626 (1983).
Ozanne, B., Fulton, R. J. & Kaplan, P. L. J. cell. Physiol. 105, 163–180 (1980).
Kaplan, P. L., Anderson, M. & Ozanne, B. Proc. natn. Acad. Sci. U.S.A. 79, 485–489 (1982).
Kaplan, P. L. & Ozanne, B. Cell 33, 931–938 (1983).
Marquardt, H. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4684–4688 (1983).
Bowen-Pope, D. F., Di Corletto, P. E. & Ross, R. J. Cell Biol. 96, 679–683 (1983).
Collins, M. K. L., Sinnett-Smith, J. W. & Rozengurt, E. J. biol. Chem. 258, 11689–11693 (1983).
Marquardt, H. & Todaro, G. J. J. biol. Chem. 257, 5220–5225 (1982).
Carpenter, G., Stoscheck, C. M., Preston, Y. A. & De Larco, J. E. Proc. natn. Acad. Sci. U.S.A. 80, 5627–5630 (1983).
Cohen, S., Ushiro, H., Stoscheck, C. & Chinkers, M. J. biol. Chem. 257, 1523–1531 (1982).
Buhrow, S. A., Cohen, S. & Staros, J. V. J. biol. Chem. 257, 4019–4022 (1982).
Cohen, S., Fava, R. A. & Sawyer, S. T. Proc. natn. Acad. Sci. U.S.A. 79, 6237–6241 (1982).
Buhrow, S. A., Cohen, S., Garbers, D. L. & Staros, J. V. J. biol. Chem. 258, 7824–7827 (1983).
Bishop, J. M. Rev. Biochem. 52, 301–354 (1983).
Yamamoto, T., Nishida, T., Miyajima, N., Kawai, S., Ooi, T. & Toyoshima, K. Cell 35, 71–78 (1983).
Adamson, E. D. & Rees, A. R. Molec. cell. Biochem. 34, 129–152 (1981).
Linsley, P. S., Das, M. & Fox, C. F. in Membrane Receptors Vol. B11 (eds Jacobs, S. & Cuatrecasas, P.) 87–113 (Chapman & Hall, London, 1981).
Schreiber, A. B., Lax, I., Yarden, Y., Eshhar, Z. & Schlessinger, J. Proc. natn. Acad. Sci. U.S.A. 78, 7535–7539 (1981).
Waterfield, M. D. et al. J. Cell Biochem. 20, 149–161 (1982).
Kawamoto, T. et al. Proc. natn. Acad. Sci. U.S.A. 80, 1337–1341 (1983).
Richert, N. D., Willingham, M. C. & Pastan, I. J. biol. Chem. 258, 8902–8907 (1983).
Gregoriou, M. & Rees, A. R. Cell Biol. Int. Rep. 7, 539–540 (1983).
Schlessinger, J., Lax, I., Yarden, Y., Kanety, H. & Libermann, T. A. in Receptors and Recognition: Antibodies against Receptors (ed. Greaves, M. F.) (Chapman and Hall, London, in the press).
Fabricant, R. N., De Larco, J. E. & Todaro, G. J. Proc. natn. Acad. Sci. U.S.A. 74, 565–569 (1977).
Wrann, M. M. & Fox, C. F. J. biol. Chem. 254, 8083–8086 (1979).
O'Keefe, E., Hollenberg, M. D. & Cuatrecasas, P. Archs biochem. Biophys. 164, 518–526 (1974).
Gullick, W., Downward, D. J. H., Marsden, J. J. & Waterfield, M. D. Analyt. Biochem. (in the press).
Ui, N. Analyt. Biochem. 97, 65–71 (1979).
Skehel, J. J. & Waterfield, M. D. Proc. natn. Acad. Sci. U.S.A. 72, 93–97 (1975).
Waterfield, M. D. & Scrace, G. T. in Biological/Biomedical Applications of Liquid Chromatography Vol. 18 (ed. Hawk, G. L.) 135–157 (Dekker, New York, 1981).
Bennett, H. P. J., Browne, C. A. & Solomon, S. J. Liquid Chromat. 3, 1353–1365 (1980).
Hewick, R. M., Hunkapiller, M. W., Hood, L. E. & Dreyer, W. J. J. biol Chem. 256, 7990–7997 (1981).
Waterfield, M. D., Scrace, G. & Totty, N. in Practical Protein Biochemistry (eds Darbre, A. & Waterfield, M. D.) (Wiley, New York, in the press).
Wilbur, W. J. & Lipman, D. J. Proc. natn. Acad. Sci. U.S.A. 80, 726–730 (1983).
Mayes, E. L. V. & Waterfield, M. D. EMBO J. (in the press).
Vennström, B. & Bishop, J. M. Cell 28, 135–143 (1983).
Kitamura, N., Kitamura, A., Toyoshima, K., Hirayama, Y. & Yoshida, M. Nature 297, 205–208 (1982).
Goodfellow, P. N., Banting, G., Waterfield, M. D., Ozanne, B. Cytogenet. cell. Genet. 32, 282 (1982).
Shimizu, N., Behzadian, M. A. & Shimizu, Y. Proc. natn. Acad. Sci. U.S.A. 77, 3600–3604 (1980).
Kondo, I. & Shimizu, N. Cytogenet, cell. Genet. 35, 9–14 (1983).
Spurr, N. et al. EMBO J. 3, 159–163 (1984).
Greenberg, M. E. & Edelman, G. M. Cell 33, 767–779 (1983).
Groffen, J., Heisterkamp, N., Reynolds, F. H. Jr. & Stephenson, J. R. Nature 304, 167–169 (1983).
Hayman, M. J., Ramsay, G. M., Savin, K., Kitchener, G., Graf, T. & Beug, H. Cell 32, 579–588 (1983).
Privalsky, M. L., Sealy, L., Bishop, J. M., McGrath, J. P. & Levinson, A. D. Cell 32, 1257–1267 (1983).
Beug, H., Palmieri, S., Freudenstein, C., Zentgraf, H. & Graf, T. Cell 28, 907–919 (1982).
Graf, T. & Beug, H. Cell 34, 7–9 (1983).
Frykberg, L. et al. Cell 32, 227–238 (1983).
Fung, Y-K. T., Lewis, W. G., Crittenden, L. B. & Kung, H-J. Cell 33, 357–368 (1983).
Rabbitts, T. H., Forster, A., Baer, R. & Hamlyn, P. H. Nature 306, 806–809 (1983).
Rabbitts, T. H., Hamlyn, P. H. & Baer, R. Nature 306, 760–765 (1983).
Gelmann, E. P., Psallidopoulos, M. C., Papas, T. S. & Favera, R. D. Nature 306, 799–803 (1983).
Roy-Burman, P., Devi, B. G. & Parker, J. W. Int. J. Cancer 32, 185–191 (1983).
Reddy, E. P., Smith, M. J. & Srinivasan, A. Proc. natn. Acad. Sci. U.S.A. 80, 3623–3627 (1983).
Bradford, M. M. Analyt. Biochem. 72, 248–254 (1976).
Smith, C. M. et al. Am. J. Obstet. Gynec. 128, 190–196 (1977).
Laemmli, U. K. Nature 227, 680–685 (1970).
Schwartz, D., Tizzard, R. & Gilbert, W. Cell 32, 853–869 (1983).
Smart, J. E. et al. Proc. natn. Acad. Sci. U.S.A. 78, 6013–6017 (1981).
Orr, H. T., Lancet, D., Robb, R. Lopez de Castro, J. A. & Strominger, J. L. Nature 282, 266–270 (1979).
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Downward, J., Yarden, Y., Mayes, E. et al. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 307, 521–527 (1984). https://doi.org/10.1038/307521a0
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DOI: https://doi.org/10.1038/307521a0
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