Abstract
Cells typically carry receptors for several excitatory and/or inhibitory agonists. In many cases the pattern of response observed is characteristic of the particular agonist used1–4. These differences in the nature of the responses cannot always be explained on the basis that the agonists use different intracellular second messengers3–5. For example, in the blood platelet, Ca2+ seems to be the second messenger6 for such excitatory agonists as ADP, adrenaline, thrombin, collagen and 11-epoxy-methanoprostaglandin H2 (U-46619). These agonists cause secretion of serotonin, ADP and ATP from the amine storage granules whereas secretion of acid hydrolases from the lysosomes has been reported to occur only on stimulation by higher concentrations of collagen and thrombin7–11. We have investigated this agonist selectivity and report here results suggesting that it is not related to cytosolic Ca2+ concentration.
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Knight, D., Hallam, T. & Scrutton, M. Agonist selectivity and second messenger concentration in Ca2+-mediated secretion. Nature 296, 256–257 (1982). https://doi.org/10.1038/296256a0
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DOI: https://doi.org/10.1038/296256a0
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