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Properties of postsynaptic channels induced by acetylcholine in different frog muscle fibres

Nature volume 291, pages 162–165 (1981)Cite this article

Abstract

Skeletal muscles in the frog are composed of two distinct classes of muscle fibre: fast muscle fibres capable of propagating action potentials and twitches, and slow muscle fibres normally unable to generate action potentials or twitches1,2. In addition, amphibian muscles contain a spectrum of ‘intermediate’ fibres whose structural and functional properties lie between those of fast and slow fibres3–6. Much is now known about the characteristics of the channels opened by the transmitter acetylcholine (ACh) acting on the membrane of fast fibres7,8, but the molecular action of ACh on the other fibre types is only poorly understood. We report here the existence of a muscle in the mandibular arch of the frog in which most, if not all, the fibres are multiply innervated and are capable of eliciting action potentials. We also report that the channels induced by the transmitter on the synaptic membrane of fast, slow and submaxillaris muscle fibres differ in their lifetimes and conductances.

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References

  1. Taski, I. & Mizutani, K. Jap. J. med. Sci. Biol. 10, 237–244 (1944).

    Google Scholar 

  2. Kuffler, S. W. & Vaughan Williams, E. M. J. Physiol., Lond. 121, 289–317 (1953).

    Article  CAS  Google Scholar 

  3. Smith, R. S. & Ovalle, W. K. J. Anat. 116, 1–24 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Lännergren, J. Nature. 279, 254–256 (1979).

    Article  ADS  Google Scholar 

  5. Kordylewski, L. Z. mikrosk-anat. Forsch. 93, 225–243 (1979).

    CAS  PubMed  Google Scholar 

  6. Kordylewski, L. Z. mikrosk-anat. Forsch. 93, 1038–1050 (1979).

    CAS  PubMed  Google Scholar 

  7. Katz, B. & Miledi, R. J. Physiol., Lond. 224, 665–700 (1972).

    Article  CAS  Google Scholar 

  8. Anderson, C. R. & Stevens, C. F. J. Physiol., Lond. 235, 655–692 (1973).

    Article  CAS  Google Scholar 

  9. Ecker, A. & Wiedersheim, R. Anatomie des Frosches (Braunschweig, Vieweg, 1896).

    Google Scholar 

  10. Stefani, E. & Steinbach, A. B. J. Physiol., Lond. 203, 383–401 (1969).

    Article  CAS  Google Scholar 

  11. Burke, W. & Ginsborg, B. L. J. Physiol., Lond. 132, 587–598 (1956).

    Google Scholar 

  12. Katz, B. & Miledi, R. Proc. R. Soc. B161, 496–503 (1965).

    ADS  CAS  Google Scholar 

  13. Katz, B. & Miledi, R. J. Physiol., Lond. 181, 656–670 (1965).

    Article  CAS  Google Scholar 

  14. Dionne, V. E. & Parsons, R. L. Nature 274, 902–904 (1978).

    Article  ADS  CAS  Google Scholar 

  15. Magazanik, L. G., Fedrov, V. V. & Snetkov, V. A. Prog. Brain Res. 49, 225–240 (1979).

    Article  CAS  Google Scholar 

  16. Kordǎs, M. J. Physiol., Lond. 204, 493–502 (1969).

    Article  Google Scholar 

  17. Katz, B. & Miledi, R. J. Physiol., Lond. 231, 549–574 (1973).

    Article  CAS  Google Scholar 

  18. Miledi, R. J. Physiol., Lond. 151, 1–23 (1960).

    Article  CAS  Google Scholar 

  19. Elul, R., Miledi, R. & Stefani, E. Acta physiol. latinoam. 20, 194–226 (1970).

    CAS  Google Scholar 

  20. Miledi, R., Stefani, E. & Steinbach, A. B. J. Physiol., Lond. 217, 737–754 (1971).

    Article  CAS  Google Scholar 

  21. Uchitel, O. D. Acta physiol. latinoam. 25, 462–466 (1975).

    CAS  Google Scholar 

  22. Schmidt, H. in Plasticity of Muscle (ed. Pette, D.) (de Gruyter, Berlin, (1980).

    Google Scholar 

  23. Cordoba, F. et al. J. Physiol., Lond. 291, 73P (1979).

    CAS  PubMed  Google Scholar 

  24. Pearse, A. G. Histochemistry, Theoretical and Applied (Churchill Livingstone, London, 1972).

    Google Scholar 

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Authors and Affiliations

  1. Department of Biophysics, University College London, Gower Street, London, WC1E 6BT, UK

    R. Miledi & O. D. Uchitel

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  1. R. Miledi
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  2. O. D. Uchitel
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Miledi, R., Uchitel, O. Properties of postsynaptic channels induced by acetylcholine in different frog muscle fibres. Nature 291, 162–165 (1981). https://doi.org/10.1038/291162a0

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