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Cell cycle and experimental pattern duplication in the chick wing during embryonic development

Abstract

Transient stimulation of cell division within chick wingbud mesenchyme is associated with the reorganization of limb patternthat follows insertion of a small graft from the posterior zone oflimb polarizing activity into the anterior border of a host bud. This increase is initiated as an enhanced rate of entry to S phase, correlated with a decrease in packing density among mesenchyme cells, through much of the limb rudiment a few hours after the operations

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References

  1. Stoker, M. J. in Paediatrics and Growth (ed. Barltrop, D.) 5–14 (Fellowship of Postgraduate Medicine, London, 1978).

    Google Scholar 

  2. Edelman, G. M. Science 192, 218–226 (1976).

    Article  ADS  CAS  Google Scholar 

  3. Daughaday, W. H., Herington, A. C. & Phillips, L. S. A. Rev. Physiol. 37, 211–244 (1975).

    Article  CAS  Google Scholar 

  4. Bullough, W. S. The Evolution of Differentiation (Academic, London, 1967).

    Google Scholar 

  5. Wolpert, L. Curr. Topics Dev. 6, 183–224 (1971).

    Article  CAS  Google Scholar 

  6. Bohn, H. Wilhelm Roux Arch. EntwMech. Org. 165, 303–332 (1970).

    Article  Google Scholar 

  7. French, V. & Bulliere, D. C. r. hebd. Séanc. Acad. Sci., Paris 280, 253–257 (1975).

    Google Scholar 

  8. Kieny, M., Mauger, A. & Sengel, P. Devl Biol. 28, 142–161 (1972).

    Article  CAS  Google Scholar 

  9. Lewis, J. H. & Wolpert, L. J. theor. Biol. 62, 479–490 (1976).

    Article  CAS  Google Scholar 

  10. Beach, D. & Jacobson, M. J. comp. Neurol. 183, 625–632 (1979).

    Article  CAS  Google Scholar 

  11. Cooke, J. J. Embryol exp. Morph. 51, 165–182 (1979).

    CAS  PubMed  Google Scholar 

  12. Cooke, J. Nature 254, 196–199 (1975).

    Article  ADS  CAS  Google Scholar 

  13. Dan-Sohkawa, M. & Sato, N. J. Embryol. exp. Morph. 46, 171–185 (1978).

    CAS  PubMed  Google Scholar 

  14. French, V., Bryant, P. J. & Bryant, S. V. Science 193, 969–981 (1976).

    Article  ADS  CAS  Google Scholar 

  15. Cooke, J. A. Rev. Biophys. Bioengng 4 (1975).

  16. Saunders, J. W. Jr & Gasseling, M. T. in Epithelial-Mesenchymal Interactions (eds Fleischmajer, R. & Billingham, R. E.) 78–79 (Williams and Wilkins, Baltimore, 1968).

    Google Scholar 

  17. Summerbell, D. & Tickle, C. in Br. Soc. dev. Biol. Symp. 3 (eds Ede, D. A., Balls, M. & Hinchliffe, M.) 41–53 (Cambridge University Press, 1977); Tickle, C., Summerbell, D. & Wolpert, L. Nature 254, 199–202 (1975).

    Google Scholar 

  18. Summerbell, D. & Wolpert, L. Nature 244, 228–230 (1973).

    Article  ADS  CAS  Google Scholar 

  19. Summerbell, D. J. Embryol. exp. Morph. 32, 227–237 (1974).

    CAS  PubMed  Google Scholar 

  20. Smith, J. A. & Martin, L. Proc. natn. Acad. Sci. U.S.A. 70, 1263–1267 (1973).

    Article  ADS  CAS  Google Scholar 

  21. Graham, C. F. & Morgan, R. W. Devl biol. 14, 439–460 (1966).

    Article  Google Scholar 

  22. Wolfsberg, M. F. Expl Cell Res. 35, 119–132 (1964).

    Article  CAS  Google Scholar 

  23. Stark, R. J. & Searls, R. L. Devl Biol. 33, 138–153 (1972).

    Article  Google Scholar 

  24. Summerbell, D. J. Embryol. exp. Morph. 50, 217–233 (1979).

    CAS  PubMed  Google Scholar 

  25. Iten, L. E. & Murphy, D. J. Devl Biol. 75, 373–385 (1980).

    Article  CAS  Google Scholar 

  26. Summerbell, D. & Lewis, J. H. J. Embryol. exp. Morph. 33, 621–643 (1975).

    CAS  PubMed  Google Scholar 

  27. Cairns, J. in Br. Soc. dev. Biol. Symp. 3 (eds Ede, D. A., Hinchliffe, J. R. & Balls, M.) 123–138 (Cambridge University Press, 1977).

    Google Scholar 

  28. Turing, A. M. Phil. Trans. B237, 37–72 (1952).

    Google Scholar 

  29. Newman, S. A. Science 205, 662–668 (1979).

    Article  ADS  CAS  Google Scholar 

  30. Summerbell, D., Lewis, J. H. & Wolpert, L. Nature 244, 492–496 (1973).

    Article  ADS  CAS  Google Scholar 

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Cooke, J., Summerbell, D. Cell cycle and experimental pattern duplication in the chick wing during embryonic development. Nature 287, 697–701 (1980). https://doi.org/10.1038/287697a0

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