Abstract
Phosphate moieties bind frequently at N-termini of helices in proteins. It is shown that this corresponds with an optimal interaction of the helix dipole and the charged phosphate. This favourable arrangement may have been discovered several times during evolution. In some enzymes, the helix dipole might be used in catalysis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wada, A. Adv. Biophys. 9, 1–63 (1976).
Poland, D. & Scheraga, H. A. Biochemistry 6, 3791–3800 (1967).
Berendsen, H. J. C. Report on CECAM Workshop Models in Protein Dynamics 299–304 (CECAM, Orsay, France, 1976).
Mayhew, S. G. & Ludwig, M. L. Enzymes 12, 57–118 (1975).
Moras, D. et al. J. biol. Chem. 250, 9137–9162 (1975).
Biesecker, G., Ieuan Harris, J., Thierry, J. C., Walker, J. E. & Wonacott, A. J. Nature 266, 328–333 (1977).
Brändén, C. I., Jörnvall, H., Eklund, H. & Furugren, B. Enzymes 11, 103–190 (1975).
Rossmann, M. G., Liljas, A., Brändén, C. I. & Banaszak, L. J. Enzymes 11, 61–102 (1975).
Banner, O. W. et al. Nature 255, 609–614 (1975).
Hammes, G. G. & Schimmel, P. R. Enzymes 2, 67–114 (1970).
Kraut, J. A. Rev. Biochem. 46, 331–358 (1977).
Robertus, J. D., Kraut, J., Alden, R. A. & Birktoft, J. J. Biochmistry 11, 4293–4303 (1972).
Glazer, A. N. & Smith, E. L. Enzymes 3, 501–546 (1971).
Drenth, J., Kalk, K. H. & Swen, H. M. Biochemistry 15, 3731–3738 (1976).
Drenth, J., Swen, H. M., Hoogenstraaten, W. & Sluyterman, L. A. AE. Kon. Nederl. Akad. Wetensch. 78, 104–110 (1974).
Garavito, R. M., Rossmann, M. G., Argos, P. & Eventoff, L. W. Biochemistry 16, 5065–5071 (1977).
Ieuan Harris, J. & Waters, M. Enzymes 13, 1–49 (1976).
Westley, J. Adv. Enzym. 39, 327–368 (1973).
Ploegman, J. H. et al. Nature 273, 124–129 (1978).
Ploegman, J. H. et al. Nature 273, 124–129 (1978).
Schlesinger, P. & Westley, J. J. biol. Chem. 249, 780–788 (1974).
Birktoft, J. J. & Blow, D. M. J. molec. Biol. 68, 187–240 (1972).
Shotton, D. M. & Watson, H. C. Nature 225, 811–816 (1970).
Stroud, R. M., Kay, L. M. & Dickerson, R. E. J. molec. Biol. 83, 185–208 (1974).
Bode, W. & Schwager, P. J. molec. Biol. 98, 693–717 (1975).
Delbaere, L. F. J., Hutcheon, W. L. B., James, M. N. G. & Thiessen, W. E. Nature 257, 758–763 (1975).
Rossman, M. G., Moras, D. & Olsen, K. W. Nature 250, 194–199 (1974).
Eventoff, W. & Rossman, M. G. CRC Critical Reviews in Biochemistry 111–140 (1974).
Schultz, G. E. & Schirmer, R. H. Nature 250, 142–144 (1974).
Ohlsson, I., Nordström, B. & Bränden, C. I. J. molec. Biol. 89, 339–354 (1974).
Holbrook, J. J., Liljas, A., Steindel, S. J. & Rossmann, M. G. Enzymes 11, 191–292 (1975).
Watenpaugh, K. D., Sieker, L. C., Jensen, L. H., Le Gall, T. & Dubourdieu, M. Proc. natn. Acad. Sci. U.S.A. 69, 3185–3188 (1972).
Burnett, R. M. et al. J. biol. Chem. 249, 4383–4392 (1974).
Olsen, K. W., Garavito, R. M., Saseban, M. N. & Rossmann, M. G. J. molec. Biol. 107, 571–576 (1976).
Phillips, D. C., Rivers, P. S., Sternberg, M. J. E., Thornton, J. M. & Wilson, I. A. Biochem. Soc. Trans. 5, 642–647 (1977).
Blow, D. M., Owen, M. G. & Nyburg, J. Biochem. biophys. Res. Commun. 67, 728–734 (1977).
Drenth, J., Jansonius, J. N., Koekoek, R. & Wolthers, B. G. Enzymes 3, 485–494 (1971).
Wright, C. S., Alden, R. A. & Kraut, J. Nature 221, 235–242 (1969).
Drenth, J., Hol, W. G. J., Jansonius, J. N. & Koekoek, R. Eur. J. Biochem. 26, 177–181 (1972).
Matthews, D. A., Alden, R. A., Birktoft, J. J., Freer, S. T. & Kraut, J. J. biol. Chem. 250, 7120–7126 (1975).
Fersht, A. Enzyme Structure and Mechanism Ch. 10 (W. H. Freeman, San Francisco and Reading, 1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hol, W., van Duijnen, P. & Berendsen, H. The α-helix dipole and the properties of proteins. Nature 273, 443–446 (1978). https://doi.org/10.1038/273443a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/273443a0
This article is cited by
-
Aerodynamics and the role of the earth’s electric field in the spiders’ ballooning flight
Journal of Comparative Physiology A (2021)
-
Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
Nature Communications (2018)
-
Local and macroscopic electrostatic interactions in single α-helices
Nature Chemical Biology (2015)
-
FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors
Leukemia (2015)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.