Abstract
ONE of the basic tenets of the clonal selection theory is that antigen-specific precursor cells bear recognition structures directed towards a single antigenic specificity. The concept of clonal selection at the level of B-cell responses is widely accepted, but the proof of clonally distributed antigen receptors on T cells is lacking. Indirect evidence for clonally distributed T cell receptors has been produced in various ways (see ref. 1 for review), but functional clones of T cells have not been conclusively demonstrated. Using modifications of techniques previously described for isolation of clones of transformed cells2 and for the production of colonies of T cells in soft agar3, we have succeeded in deriving clones of alloreactive murine T cells.
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References
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FATHMAN, C., HENGARTNER, H. Clones of alloreactive T cells. Nature 272, 617–618 (1978). https://doi.org/10.1038/272617a0
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DOI: https://doi.org/10.1038/272617a0
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