Abstract
SENDAI virus (HVJ, haemagglutinating virus of Japan), a type 1 parainfluenza myxovirus, agglutinates certain types of cells and induces cell fusion1. Previously2 we reported on the degranulating activity in the hybrid cells derived from rat mast cells and Ehrlich ascites tumour cells using HVJ. During that work, it was found that histamine release accompanied by degranulation from unfused mast cells occurred frequently. This observation led to the theory that histamine release from mast cells was induced by virus, as well as by antigen from sensitised mast cells and by histamine releasers. The results reported here indicate that histamine release from mast cells was induced by direct exposure of cells to virus in the presence of Ca2+ at 37 °C and that it was markedly enhanced by the addition of phosphatidylserine (PS), which is a selective enhancer3 of anaphylactic histamine release.
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SUGIYAMA, K. Histamine release from rat mast cells induced by Sendai virus. Nature 270, 614–615 (1977). https://doi.org/10.1038/270614a0
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DOI: https://doi.org/10.1038/270614a0
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